• Thiomyristoyl The only psychostimulant treatment option in T

  2022-12-12

  

  The only psychostimulant treatment option in Turkey is methylphenidate (Çetin et al., 2015). It is broken down by carboxylase enzyme (CES1) (Sun et al., 2004). From the point of pharmacokinetics, it may be suggested that CES1 gene polymorphisms may be the key responsible factors in patients resistan

• Cyclo In conclusion we have shown that mGlu receptors negati

  2022-12-12

  

  In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, Cyclo tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activation of noradrenergic transmis

• br Disclosure br Acknowledgement br

  2022-12-09

  

  Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal 3-isomangostin receptor in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved

• Moreover our present work suggests

  2022-12-09

  

  Moreover, our present work suggests that AXL could be a modulator of sunitinib response, at least for cell lines that present high endogenous levels of this RTK activation, since we observed an increased responsiveness to sunitinib in chemicals the full details activated with AXL receptor ligand. A

• br Conclusions br Acknowledgments br Introduction To die or

  2022-12-09

  

  Conclusions Acknowledgments Introduction To die or not to die – that is the question. Christian de Duve created the word “autophagy” in 1960’s for the first time (Klionsky et al., 2016). The word “autophagy” was derived from the Greek roots “auto” (self) and “phagy” (eating) and referred to

• The mitogen activated protein kinase

  2022-12-09

  

  The mitogen-activated protein kinase (MAPK) plays an important role in a variety of cell processes by controlling transcriptional or translational regulation [14]. There are three major MAPK family members that have been well characterized: extracellular signal-regulated kinase (ERK), c-Jun N-termin

• s6 kinase It is reported that calpain

  2022-12-09

  

  It is reported that calpain-2 plays a critical role in BDNF-induced signaling and memory formation, and knockdown of calpain-2, but not calpain-1, completely suppresses BDNF-induced pathway activation and protein translation (Briz et al., 2013). BDNF prevents neuronal apoptosis or death (Ferrer et a

• In our study caspase and

  2022-12-09

  

  In our study, caspase3 and DRAM were identified as being involved in full-length AIFM1-induced apoptosis. Caspase3 is best known for its role in the execution phase of apoptosis in both intrinsic and extrinsic apoptotic pathways [17]. The members of the caspase family are generally in inactive pro-f

• HMGN proteins are subject to extensive post translational mo

  2022-12-09

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to mek inhibitor and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]). Th

• Echinocandin resistance is systematically associated

  2022-12-09

  

  Echinocandin resistance is systematically associated with point mutations in either FSK1 or FSK2 genes [7], [104]. These mutations are located in two different not spot regions of these genes named HS1 and HS2. Hot spot mutations have been reported in C. albicans, C. glabrata, C. tropicalis, C. krus

• Therefore VEGF and its receptors

  2022-12-09

  

  Therefore, VEGF and its receptors are expressed in different organs, including the kidneys, the liver and the pemetrexed disodium mg [55]. In the human placenta, VEGF is mainly synthesized by cytotrophoblast and Hofbauer cells early in the first trimester, whereas Flk-1 and Flt-1 receptors are expr

• A has been reported to decrease insulin receptors and impair

  2022-12-09

  

  Aβ has been reported to decrease insulin receptors and impair insulin signaling in neurons, preventing phosphorylation of Akt and glycogen synthase kinase 3β (GSK-3β), downstream of insulin signaling, and to increase phosphorylation of tau protein causing neurofibrillary tangles (Tokutake et al., 20

• br Introduction Hepatocellular carcinoma HCC is the third

  2022-12-09

  

  Introduction Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related death worldwide and accounts for 70–85% of all liver cancer diagnoses [1]. In East and South-East Asia, the occurrence of HCC and the related number of fatalities have gradually increased in recent decades [2

• When arachidonic acid is used as

  2022-12-09

  

  When arachidonic telaprevir is used as a substrate, the platelet-type 12S-lipoxygenase produces predominantly the 12S-hydroperoxy derivative. In contrast, the leukocyte-type 12S-lipoxygenases generate substantial amounts of the 15-lipoxygenase product in addition to the 12S-hydroperoxy derivative.

• Salvia the largest genus in the family Lamiaceae

  2022-12-09

  

  Salvia, the largest genus in the family Lamiaceae, comprises over 900 species that are distributed globally [14], [15], [16]. The genus Salvia has been assessed in many studies because it is a rich source of polyphenol compounds, of which more than 160 have been isolated from plants in the genus, so

15772 records 343/1052 page Previous Next First page 上5页 341342343344345 下5页 Last page