• br Acknowledgement Our work is

  2018-10-24

  

  Acknowledgement Our work is supported by research grants from the Agence Nationale de la Recherche (ANR; projects PLURABBIT no. PCS-09-GENM-08 and ORYCTOGENE no. ANR-12-RPIB-0013), European Cooperation in Science and Technology (COST) Action (Rabbit Genome Biology (RGB)-Net no. TD1101), HyPharm,

• br Results Relying on the high

  2018-10-24

  

  Results Relying on the high conservation of vertebrate TBX3 proteins, we used human TBX3 in murine ESCs due to its specific traceability. We inserted human TBX3 cDNA into the pEF-DEST51 vector (Invitrogen) for EF1α-promoter-based stable and constitutive overexpression in ESCs. Out of 20 independe

• Cell transplantation therapy is a promising approach to prom

  2018-10-24

  

  Cell transplantation therapy is a promising approach to promote remyelination in MS patients; human embryonic stem Rimonabant (hESCs) and induced pluripotent stem cells, as well as fetal brain, are potential sources of therapeutic cells (Brüstle et al., 1999; Müller et al., 2006). Studies in animal

• It is thought that a

  2018-10-24

  

  It is thought that a better understanding of the molecular and cellular mechanisms that regulate the emergence and maintenance of long-term repopulating hematopoietic stem prostaglandin receptors (HSCs) during embryonic development would aid in the development of optimal protocols to generate such

• A second cellular stress pathway implicated in

  2018-10-24

  

  A second cellular stress pathway implicated in the setting of accumulated intracellular Z AAT protein is the UPR, postulated to link Z AAT polymer-induced cellular injury and downstream development of liver disease, a poorly understood progression (Lawless et al., 2004; Perlmutter et al., 2007). Pre

• With regard to prepubertal testicular

  2018-10-24

  

  With regard to prepubertal testicular tissue, an important concern for IVM is proper establishment of the blood testis barrier (BTB) during the peripubertal period. Several studies have demonstrated a correlation between dysfunction of the BTB and impaired spermatogenesis (Cavicchia et al., 1996), a

• br Conclusion br Acknowledgements br Introduction Since

  2018-10-24

  

  Conclusion Acknowledgements Introduction Since the first successful reprogramming of somatic pi3k inhibitors into induced pluripotent stem cells (iPSCs) (Takahashi and Yamanaka, 2006), countless efforts have been made to fully explore the potential applications of iPSCs in biomedical resea

• By performing selective molecular profiling with LMD we were

  2018-10-24

  

  By performing selective molecular profiling with LMD, we were able to demonstrate that the expression of many pre- and postsynaptic molecules, including Bassoon, Piccolo, Synaptophysin, Synapsin, Synaptotagmin, Vglut1, Vglut2, Vgat, Gad65, Gad67, Psd95, Homer1, and Shank1, were observed in the engra

• Mechanistically SUMO depletion may enhance

  2018-10-24

  

  Mechanistically, SUMO2 depletion may enhance iPSC formation by derepressing epigenetically silenced pluripotency loci (Poleshko et al., 2014; Yang et al., 2015) as well as histone and protein biosynthesis genes important for cellular growth and proliferation (Neyret-Kahn et al., 2013). Consistently,

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

• cftr channel Active cell proliferation is key for transcript

  2018-10-24

  

  Active cell proliferation is key for transcription factor-induced cell-fate change during cellular reprogramming. Because acute leukemias barely or do not proliferate in vitro, we endeavored to reprogram leukemic B cell lines as well as MLL-rearranged primary blasts induced to proliferate through xe

• br Results Disease modeling using iPSCs can be

  2018-10-24

  

  Results Disease modeling using iPSCs can be confounded by phenotypic variation resulting from genetic differences between individual iPSC lines (Merkle and Eggan, 2013). To overcome this obstacle, we sought to generate isogenic cell lines by targeted correction of the point mutation in the SOD1 i

• To further explore the value of feline liver

  2018-10-24

  

  To further explore the value of feline liver organoids as a research model for steatosis, we tested the effect of small molecules on lipid metabolism. Lipid accumulation was enhanced in the presence of etomoxir, indicating that β-oxidation is an important metabolic pathway handling excess fatty acid

• An approximate solution is sought in the form

  2018-10-24

  

  An approximate solution is sought in the form of an output of an artificial neural network of the given architecture: whose weights are determined when minimizing the error functional and for our case, F(x, y, α) = –α(y – cosx). Test points () are chosen to be random and distributed uniformly

• The results we obtained are also

  2018-10-24

  

  The results we obtained are also in a good agreement with the photoconductivity spectra under excitation by p- or s-polarized light in a structure similar to the one we examined, also containing wide doped QWs [10], where a broad ask1 inhibitor line associated with the 1→e1 and 1→2 transitions was

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