In this study we found that

2018-10-20

In this study, we found that while zebrafish med14 mutant embryos were largely arrested in development, there was a surprisingly limited effect on overall transcription. Transplantation experiments demonstrated that Med14 function is largely dispensable for cell survival into adulthood. Loss of med1

br Future perspectives Human fetal tissue research and non h

2018-10-20

Future perspectives Human fetal tissue research and non human primate macaque models have been essential to the establishment of human PGCLC differentiation models to study mechanisms that contribute to early PGC allocation in the embryo. Together, these approaches have revealed that humans have

RNA splicing occurs in spliceosomes

2018-10-20

RNA splicing occurs in spliceosomes, which is a complex consisting of RNA and proteins, including five small nuclear RNAs (snRNAs) (U1, U2, U4, U5, and U6 snRNA), hundreds of auxiliary protein factors, and small nuclear ribonucleoproteins (snRNPs) (Reed et al., 1988). The RNA splicing process is cat

br Results br Discussion We examined

2018-10-20

Results Discussion We examined gene expression in human intestinal tissue across the developmental continuum in order to determine maturity of in-vitro-derived HIOs. Using global RNA expression data obtained by RNA-seq, several different analyses demonstrated that the HIO transcriptome closely

Interestingly KLF and TFCP L are

2018-10-20

Interestingly, KLF2 and TFCP2L1 are also involved in LIF/STAT3-mediated ESC self-renewal. KLF2, which is functionally redundant with KLF4, a known target of LIF/STAT3 signaling, can maintain mESCs in an undifferentiated state in the presence of serum (Hall et al., 2009). TFCP2L1, a key target of LIF

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The onset of puberty is regulated by a small population of hypothalamic gonadotropin-releasing hormone (GnRH) neurons, which secrete GnRH decapeptide to the hypophyseal portal system. Unlike other neuroendocrine ce

Hello world!

2018-07-29