• br Conclusions A premise of

  2018-10-24

  

  Conclusions A premise of evolutionary thought is that each challenge a person faces can be of a different nature and therefore the motivations it mmae stimulates and the actions taken to meet that challenge are also different. For example, the motivations a man feels when he sees the pictures of

• The mayor can also emphasize in the

  2018-10-23

  

  The mayor can also emphasize in the improvement of teaching in the first years of the basic education cycle, to gain quota in the “2nd grade literacy” indicator. However, since 2004 the state government runs (alongside the federal government) a program called PAIC, Program for Literacy at the Approp

• We did not observe that epitope conservation was a

  2018-10-23

  

  We did not observe that epitope conservation was a parameter uniquely shared between LTNP/EC with and without protective alleles. An association between lower HIV RNA levels and preferential recognition of conserved epitopes has been suggested in some acute and chronic infection cohorts regardless o

• Interestingly in their simulation model Lodding and colleagu

  2018-10-23

  

  Interestingly, in their simulation model, Lodding and colleagues were able to predict their real rate of recipients with a high CMV viral load (1.4%, arbitrarily set at >18,200IU/mL) with the assumption of their lower doubling time of 4.3days. Using a shorter doubling time of 1.3days, the proportion

• This study has highlighted the complexity of operationally d

  2018-10-23

  

  This study has highlighted the complexity of operationally defining compensation in neurodegenerative diseases such as HD. The previous literature in HD has thus far failed to address this issue, instead making assumptions of putative compensation based solely on increased activation or connectivity

• Our second objective was to analyze whether certain physicia

  2018-10-23

  

  Our second objective was to analyze whether certain physician characteristics may play a role in these diagnostic and therapeutic decisions. In contrast to what might have been expected, younger cardiologists were not more aggressive than older ones. In fact, if anything, the reverse trend was obser

• Studies using conformational antibodies are indicating

  2018-10-23

  

  Studies using conformational antibodies are indicating that these strains play important roles in toxicity. Sebollela et al. (2014) have shown that NU4, a conformational monoclonal antibody, protected cultured cells from Aβ induced reactive oxygen species production. The study also found that NU4 re

• According to the FDA a

  2018-10-23

  

  According to the FDA, a prognostic in vitro diagnostic biomarker would need a 510K or de novo approval (class II device), whereas a predictive biomarker would need ldt pre-market approval (PMA, class III device). The main separating factor is that a prognostic biomarker provides you with an estimate

• Several conflicting large scale population based studies pub

  2018-10-23

  

  Several conflicting large-scale population-based studies published recently (e.g. (Lau et al., 2015; Moriya et al., 2015; Tsunoda et al., 2014)) indicated that histone methyltransferase moderate (or ‘non-alcoholic’) alcohol consumption either has a beneficial or detrimental association with prevalen

• br The last century has witnessed incredible progresses in

  2018-10-23

  

  The last century has witnessed incredible progresses in the control of infectious diseases. However, respiratory pathogens continue to threaten humans and cause serious public health and economic problems. Not only emerging pathogens but also viruses that have been known for a while continue to ca

• br Author Contributions br Role of the Funding

  2018-10-23

  

  Author Contributions Role of the Funding Source Conflict of Interest Statement Acknowledgements This work was funded by the European Commission (FP7): “SwitchBox” (Contract HEALTH-F2-2010-259772), and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte),

• Interestingly GRK down modulation similarly inhibited tumor

  2018-10-23

  

  Interestingly, GRK2 down-modulation similarly inhibited tumor growth of breast tumor cell lines-derived xenografts irrespective of their p53 status, suggesting that the ability of GRK2 to modulate tumor development in vivo is independent of the p53 status or, alternatively, that it has a double-edge

• Most chemotherapeutic drugs used clinically evoke

  2018-10-23

  

  Most chemotherapeutic drugs used clinically evoke cell apoptosis by inducing DNA damage. However, the high efficiency of DNA repair due to the overexpression of DNA repair proteins in cancer retinoid x receptor reduces the drug efficacy significantly (Fink et al., 1996, 1998). For example, the expre

• This review has several limitations First we only

  2018-10-23

  

  This review has several limitations. First, we only focused on qualitative research studies and did not include quantitative evaluation studies. Quantitative studies are necessary to establish efficacy and effectiveness. At the same time, qualitative evaluation provides valuable policy-relevant data

• In the present issue of Lupinek et al

  2018-10-23

  

  In the present issue of , Lupinek et al. address by a different approach the limit of too high total IgE levels or body mass precluding the use of omalizumab in severe asthma (). They used IgEnio (Fresenius Medical Care, Bad Homburg, Germany) a device that consist of a extracorporeal immunoadsorber

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