• Several conflicting large scale population based studies pub

  2018-10-23

  

  Several conflicting large-scale population-based studies published recently (e.g. (Lau et al., 2015; Moriya et al., 2015; Tsunoda et al., 2014)) indicated that histone methyltransferase moderate (or ‘non-alcoholic’) alcohol consumption either has a beneficial or detrimental association with prevalen

• br The last century has witnessed incredible progresses in

  2018-10-23

  

  The last century has witnessed incredible progresses in the control of infectious diseases. However, respiratory pathogens continue to threaten humans and cause serious public health and economic problems. Not only emerging pathogens but also viruses that have been known for a while continue to ca

• br Author Contributions br Role of the Funding

  2018-10-23

  

  Author Contributions Role of the Funding Source Conflict of Interest Statement Acknowledgements This work was funded by the European Commission (FP7): “SwitchBox” (Contract HEALTH-F2-2010-259772), and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte),

• Interestingly GRK down modulation similarly inhibited tumor

  2018-10-23

  

  Interestingly, GRK2 down-modulation similarly inhibited tumor growth of breast tumor cell lines-derived xenografts irrespective of their p53 status, suggesting that the ability of GRK2 to modulate tumor development in vivo is independent of the p53 status or, alternatively, that it has a double-edge

• Most chemotherapeutic drugs used clinically evoke

  2018-10-23

  

  Most chemotherapeutic drugs used clinically evoke cell apoptosis by inducing DNA damage. However, the high efficiency of DNA repair due to the overexpression of DNA repair proteins in cancer retinoid x receptor reduces the drug efficacy significantly (Fink et al., 1996, 1998). For example, the expre

• This review has several limitations First we only

  2018-10-23

  

  This review has several limitations. First, we only focused on qualitative research studies and did not include quantitative evaluation studies. Quantitative studies are necessary to establish efficacy and effectiveness. At the same time, qualitative evaluation provides valuable policy-relevant data

• In the present issue of Lupinek et al

  2018-10-23

  

  In the present issue of , Lupinek et al. address by a different approach the limit of too high total IgE levels or body mass precluding the use of omalizumab in severe asthma (). They used IgEnio (Fresenius Medical Care, Bad Homburg, Germany) a device that consist of a extracorporeal immunoadsorber

• One of the limitations of this study is the

  2018-10-23

  

  One of the limitations of this study is the differences in the patient populations between the two CRC patient cohorts. As shown in Table 1 and 2, there were differences in the number of patients with stage IV CRC between cohort 1 and cohort 2. At first, we validated the clinical significance of SNO

• br Microorganism cultivation and secretome extraction The fu

  2018-10-23

  

  Microorganism cultivation and secretome extraction The fungal isolates belonging to Aspergillus sp. isolated, identified and labeled as A. fumigatus LF9 was used in this study [3]. DNA sequence of this isolate is available in GenBank under accession no. JF815073. A. fumigatus LF9 was cultivated a

• Introduction ZrB is the leading material

  2018-10-22

  

  Introduction ZrB2 is the leading material among ultra-high-temperature ceramics due to its high melting point (3245 °C), high hardness (23 GPa), high thermal conductivity (∼60 W m−1 ·k−1), electrical conductivity (∼107 S m−1), and relatively low density (6.09 g cm−3), high strength at elevated temp

• Among patients patients were diagnosed with hypertension fol

  2018-10-22

  

  Among 200 patients, 77 (38.5%) patients were diagnosed with hypertension, followed by 55 (27.5%) with diabetes, 50 (25%) with urinary tract infections and other diseases are summarized in Table 5. Majority of observed medication errors were found with drug class belonging to gpr109a inhibitor 9 (22.

• br Results and discussion In Fig a

  2018-10-22

  

  Results and discussion In Fig. 6a and b, four electrical impedance signals are shown, those were taken for each supporting substances (Black silicone, white gypsum, green gypsum, acrylic) with the BBPS device. Each specimen was mounted in a press to constraint each supporting substance, as depict

• Senexin B The gold standard of identification

  2018-10-22

  

  The gold standard of identification by bacterial culture has been unable to meet the demand of bacterial Senexin B analysis, because >90% of the clinical bacteria cannot be cultured. Next-generation sequencing (NGS) provides a new technology to study the microbiota and pathogenic mechanisms. 16S r

• br On history What is the history

  2018-10-22

  

  On history What is the history of architecture for Banham? History as a system of knowledge is undoubtedly important for Banham because of its resourceful nature for future improvement and correction. Even though historical accounts on Banham\'s works have been the main concern of Whiteley\'s boo

• br Materials and methods br Results and discussion br Discus

  2018-10-22

  

  Materials and methods Results and discussion Discussion Conclusions Islamic architectural design and construction combine various secular and religious styles that span the Islamic history. The bulk of Islamic architectural characteristics is visible in mosques, tombs, forts, and palaces

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