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In Bogot a city situated at a high altitude
2018-11-07
In Bogotá, a city situated at a high altitude (2640m above sea level), the normal SpO2 during wakefulness is found between 90 and 92% [8–12]. Unlike the observed sea level, a decrease of 3% or higher from this point, which is the criterion to define the presence of hypopnea, necessarily implicates t
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Apart from these measurable effects and the subjective
2018-11-07
Apart from these measurable effects and the subjective feeling of disturbed sleep, people who struggle with nocturnal environmental noise often also suffer the next day from daytime sleepiness and tiredness, annoyance, mood changes as well as decreased well-being and cognitive performance [1,4,10,39
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br Methods br Results br Discussion While
2018-11-07
Methods Results Discussion While the critical role of epigenetic regulators in disease development is becoming widely recognized, epigenetic regulations in vascular diseases, in particular restenosis, are less well understood (Alexander and Owens, 2012). The BET family is a class of epigene
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Conflict of Interest br Iwayama s paper in
2018-11-07
Conflict of Interest Iwayama\'s paper in () may provide a significant advance in exercise-based strategies for the management of obesity and metabolic diseases. It demonstrates with a careful methodology that a bout of endurance exercise at moderate intensity (50% VOmax), when performed at fast,
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Another possible cause of marginal effects
2018-11-07
Another possible cause of marginal effects of transplanted encapsulated islets was fibrosis of zip inhibitor after transplantation as indicated in the histology study. Though, the histology study was not performed for quantitative analysis. It was demonstrated that microcapsule could prevent direct
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Like other natural history cohorts
2018-11-07
Like other natural history cohorts, rapid disease progression was observed at a 7–9% frequency regardless of HIV-1 subtype but slow progressors/controllers appeared only in subtype A and C infections. The differential rates of CD4 T-cell declines (D>A>C) was still significant when rapid progressors
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pppa br Acknowledgements The authors would
2018-11-07
Acknowledgements The authors would like to thank Patricia Lemnitzer, Yvonne Jansen, Janine Brauner, and Sebastian Cucuruz for excellent technical assistance. The graphical abstract was designed by Patrick Paulin ([email protected]). We thank Lars König for providing HepG2 cells. Introd
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In conclusion the present study provides the comprehensive e
2018-11-07
In conclusion, the present study provides the comprehensive examination of the beneficial consequences of therapeutic doses of metformin in the PCOS-like rat uterus (Fig. 8). Strategies to treat PCOS-related reproductive disturbances, including long-term treatment with metformin, remain unstandardiz
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br Funding Sources This work was
2018-11-07
Funding Sources This work was supported by the National Institute of Allergy and Infectious Disease Grants: AI102435, AI120364, and AI122399. The funding sources had no role in the writing of this manuscript or the decision to submit it for publication. Conflict of Interest Statement Author
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br Interventions that Harness CR s Mechanisms Caloric
2018-11-07
Interventions that Harness CR\'s Mechanisms Caloric restriction as an intervention is likely to be very difficult to implement in humans. Indeed the goal of CR research is to figure out how it works, not to promote it as a lifestyle. In order to gain the beneficial effects of CR without the restr
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To investigate the translatability of CR s beneficial effect
2018-11-07
To investigate the translatability of CR\'s beneficial effects from rodents to primates, three independent rhesus monkey studies were initiated in the late 1980\'s. Two of these studies are ongoing: one at the National Institute on Aging (NIA) and the other at the Wisconsin National Primate Researc
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Since IM oxytocin reaches its site
2018-11-07
Since IM oxytocin reaches its site of action, the uterus, via the plasma it is proposed that demonstrating a comparable plasma drug profile following IH and IM routes of administration allows for extrapolation from the extensive clinical safety and efficacy data for the approved IM oxytocin product
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To functionally express and determine the ligand selectivity
2018-11-07
To functionally express and determine the ligand selectivity of the stingray (sr) MC1R, srMC2R, srMC3R, srMC4R, and srMC5R paralogs, the nucleotide sequences for the srmcrs were separately synthesized with a V-5 epitope tag at the N-terminal of the receptor, and inserted into a pcDNA3.1 expression v
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Studies have also looked at the development of
2018-11-07
Studies have also looked at the development of reappraisal in the regulation of appetitive cravings for unhealthy foods (Silvers et al., 2014; Giuliani and Pfeifer, 2015). In a recent study, females aged 10–23 were asked to use reappraisal to reduce cravings (Giuliani and Pfeifer, 2015). Across all
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Notable strengths of the study include acquisition of spectr
2018-11-07
Notable strengths of the study include acquisition of spectral data through the use of 2D-JPRESS at 4.0T, which permits improved spatial and spectral resolution, high SNR afforded by high field MRS, and optimal detection of Glu separately from Gln. However, it should be noted that the MRS technique
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