• In addition to classical receptor targets such as

  2018-11-05

  

  In addition to ‘classical’ receptor targets such as EGFR (Roovers et al., 2007,2011; Schmitz et al., 2013; Omidfar et al., 2013), HER2 (Jamnani et al., 2012; Even-Desrumeaux et al., 2012), c-MET (Slordahl et al., 2013) and VEGFR (Behdani et al., 2012), nanobodies against new targets such as the DR5

• According to HCV status we found a

  2018-11-05

  

  According to HCV status, we found a stronger association between low TGF-β1 concentrations and the risk of death from HCC among the HCV-positive group compared to the HCV-negative group, suggesting that the predictive value of TGF-β1 is more potent in higher risk HCV-positive individuals. This findi

• HLA transgenic mice are widely used to model

  2018-11-05

  

  HLA-transgenic mice are widely used to model the human T cell response in mice. We focused the present study on the HLA B*0702 allele, which is associated with strong T cell response in terms of magnitude and breath (Weiskopf et al., 2013), thereby allowing us to test the role of multiple cross-reac

• Glucose stimulated insulin secretion GSIS

  2018-11-05

  

  Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is biphasic, and suppression of the first-phase GSIS is one of the most characteristic findings of β-cell dysfunction in type 2 diabetes (). Consistently, decreased early insulin response is associated with post-prandial hyperglycem

• The data from this study make important contributions to our

  2018-11-05

  

  The data from this study make important contributions to our knowledge of immune responses to Zika virus and to the development of effective vaccines against Zika. The authors utilized purified E protein, which was characterized by low protein yields, indicating that prM protein may be required for

• Given the competing roles described above an

  2018-11-05

  

  Given the competing roles described above, an important question is whether treatment of cancer by autophagy inhibition will lead to neurodegenerative side effects and likewise, that treatment of neurodegenerative diseases with autophagy promoting agents might promote pre-malignant tumors. There are

• br Introduction Narcolepsy is a chronic disturbance that lea

  2018-11-05

  

  Introduction Narcolepsy is a chronic disturbance that leaves patients incapacitated in most cases; it is characterized by an abnormal sleep pattern that may include excessive daytime sleepiness, sleep architecture alterations, and rapid eye movement (REM) sleep pathological manifestations, includ

• In Bogot a city situated at a high altitude

  2018-11-05

  

  In Bogotá, a city situated at a high altitude (2640m above sea level), the normal SpO2 during wakefulness is found between 90 and 92% [8–12]. Unlike the observed sea level, a decrease of 3% or higher from this point, which is the criterion to define the presence of hypopnea, necessarily implicates t

• br Disclosure statement br Acknowledgements

  2018-11-05

  

  Disclosure statement Acknowledgements The authors thank Australian Wool Innovation Ltd (AWI) for financial support for the project that yielded material discussed in this article. Introduction Scientific study of human sleep has been initiated by the discovery that sleep progresses through

• Sleep curtailment is able to change food

  2018-11-05

  

  Sleep curtailment is able to change food intake as a result of decreased secretion of leptin [59–61] and increased secretion of ghrelin [49,59,62], which leads to increased food intake [49]. Two consecutive nights of sleep restriction (4h of time in bed) in young men were associated with a 28% incre

• This study is important as it

  2018-11-05

  

  This study is important as it tried to measure the sleep quality (through consecutive measurements) by simultaneously controlling the intervening variables (suffering from medical disorders, psychological disorders, abusing other substances, using psychotherapeutic medications, lapse and relapse) du

• br pasado de diciembre de el Ejecutivo Federal public

  2018-11-05

  

  pasado 20 de diciembre de 2013 el Ejecutivo Federal publicó el Decreto que modifica la Constitución Política Mexicana en materia de energía, con lo cual puso en marcha la reforma estructural del sector, anunciada reiteradamente como objetivo prioritario de Gobierno. modificación comprende los Ar

• br Phosphorylated proteins were enriched from

  2018-11-03

  

  Phosphorylated proteins were enriched from the total protein extract using the Al(OH)3-MOAC method as previously described with modifications [6]. Approximately 8mg of total protein extract was added to 2g of Al(OH)3. After centrifugation (6000g for 10min), the matrix with retained proteins was wa

• br Data sets and attributes

  2018-11-03

  

  Data sets and attributes The data published here are organized in two ‘csv’ files, ‘rawdata.csv.gz’ (4.5MB) and ‘features.csv’ (200kB). The raw data are stored in the first file ‘rawdata.csv.gz’, where each line represents a single measurement per sensor. Consequently, one needs to read specific

• Three key factors were considered for selecting catchment

  2018-11-03

  

  Three key factors were considered for selecting catchment areas from a topographic map that were suitable for harnessing hydropower. The key factors were polo like kinase demand, accessibility and river profile. The catchment areas topographies were studied for determining the appropriate elevation

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