• br Introduction This article deals with the relation

  2018-11-09

  

  Introduction This article deals with the relation between innovation and employment at the firm level. Our focus is on formalized and structured innovation, i.e. new products and/or processes generated by an initial R&D expenditure. As explained by Dosi (1988) and Pavitt (1984), innovation strate

• It has been suggested that similarly to

  2018-11-08

  

  It has been suggested that similarly to embryonic stem buy RGFP966 (ESCs), stemness-related properties of some stromal stem/progenitor cells are supported by regulatory networks of transcription factors OCT4, SOX2 and NANOG (Greco et al., 2007; Ng and Surani, 2011; Park et al., 2012; Riekstina et a

• Besides their direct effect on cartilage ASCs might act on

  2018-11-08

  

  Besides their direct effect on cartilage, ASCs might act on the other joint tissues as synovial membrane, ligaments, meniscus and subchondral bone that are also altered in OA. Although OA is not considered an inflammatory disease, pro-inflammatory cytokines, namely IL-1β and TNF-α, are secreted by O

• PF-573228 Murine haematopoiesis first occurs in the extra

  2018-11-08

  

  Murine haematopoiesis first occurs in the extra-embryonic yolk sac around embryonic day 7.5 with the formation of blood islands containing primitive erythrocytes surrounded by developing endothelial cells (Ferkowicz and Yoder, 2005; Moore and Metcalf, 1970; Palis et al., 1999; Palis and Yoder, 2001)

• br Sources of chick stem cells br Applications and

  2018-11-08

  

  Sources of chick stem cells Applications and technologies related to chick stem cells Conclusions Conflict of interest Acknowledgments The authors\' work was supported by the Medical Research Council (MRC) and a Ph.D. scholarship from the programme “Strategic Scholarships for Frontier

• br H AZ histone exchange H AZ is incorporated within

  2018-11-08

  

  H2AZ histone exchange H2AZ is incorporated within nucleosomes via ATP-dependent activities. The complexes mediating H2AZ-H2A exchanges are well characterized in Saccharomyces cerevisiae and include the Swr1-containing SWR complex (SWR-C). The mammalian orthologue of Swr1 is SRCAP. Both complexes

• The effect of Sav or Lats

  2018-11-08

  

  The effect of Sav1 or Lats1/2 inactivation on adult cardiomyocyte proliferation has also been examined. Inactivation of these Hippo pathway components in the adult heart increased cardiomyocyte DNA synthesis and karyokinesis (Heallen et al., 2013). Qualitatively, the result was similar to what was o

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion riPSCs are typically generated and cultured on MEF feeders (Liu et al., 2008). Feeders are sufficient to support rhesus iPSC long-term maintenance. However, this approach is too labor intensive for large-scale culture. Optimization of this culture sy

• Acknowledgments This work was supported by the

  2018-11-08

  

  Acknowledgments This work was supported by the Agency for Science, Technology and Research, Singapore. We would like to thank the Cytogenetics laboratory at Singapore General Hospital for karyotyping the iPSC lines and Luqman Hakim for help in characterizing the iPSC lines. We would like to thank T

• sigma receptor Introduction The mechanisms by which pluripot

  2018-11-08

  

  Introduction The mechanisms by which pluripotency regulators dictate self-renewal versus differentiation are only recently being studied (Wagner et al., 2010; Niwa et al., 2009). In addition, various approaches are being developed to examine such processes (Wang et al, 2013). The transcriptional re

• Human DSTN and CFL are more than identical

  2018-11-08

  

  Human DSTN and CFL1 are more than 70% identical in amino Cy3-dUTP sequence. DSTN has a much higher actin depolymerizing activity than Cofilin (Yeoh et al., 2002) which is explained by sequence differences at the F-actin-binding site (Pope et al., 2004). CFL1 deficiency is embryonic lethal at E11.5–

• br Resource table Resource details RCe A RC was derived

  2018-11-08

  

  Resource table. Resource details RCe008-A (RC-4) was derived from a fresh parp inhibitors that was surplus to requirement or unsuitable for clinical use. The cell line was derived by whole embryo outgrowth on a chemically defined matrix consisting of laminin, fibronectin, Collagen IV and vitrone

• C MYC was found to act as a

  2018-11-08

  

  C-MYC was found to act as a driver for the malignant conversion of precursors lesions into HCC (Kaposi-Novak et al., 2009). In fact, HCC, and c-MYC may indeed be responsible for the maintenance and progression of the cancer. This is supported by data of a genetically engineered mouse model in which

• In human development OPCs are characterized by

  2018-11-08

  

  In human development, OPCs are characterized by PDGFRα and NG2 expression, followed by expression of O4 (Jakovcevski et al., 2009). Under our culture conditions, by day 75, most of the O4+ cells had lost PDGFRα, but retained NG2 expression. At this stage, we did not observe any residual pluripotent

• Heat shock proteins as molecular chaperones are involved in

  2018-11-08

  

  Heat shock proteins, as molecular chaperones, are involved in a variety of cellular functions. Apart from their commonly known roles in maintaining protein stability and mediating the assembly and disassembly of protein complexes, recent studies have shown that certain chaperones, including HSPA8, a

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