• The PAX gene encodes a transcriptional factor

  2019-05-22

  

  The PAX5 gene encodes a transcriptional factor, which is specifically expressed at the early stages of B-cell differentiation and it is required for B-cell development. Its dysregulation is involved in the leukemogenesis of B-ALL. The PAX5 gene rearrangements account for approximately 2.5% of pediat

• Countdown to concluded its tasks after the launch of

  2019-05-22

  

  Countdown to 2015 concluded its tasks after the launch of its seventh global report at the Maternal Newborn Health conference in Mexico City, October, 2015. It is now relaunched as Countdown to 2030 (CD2030), retaining and enhancing the successful multi-institutional network with over a decade of he

• br Conclusion br Conflict of interest br Introduction Loss o

  2019-05-22

  

  Conclusion Conflict of interest Introduction Loss-of-function mutations in the cardiac sodium (Na+) channel gene have been implicated in Brugada syndrome, progressive cardiac conduction defect (PCCD), sick sinus syndrome, and idiopathic ventricular fibrillation (IVF) [1]. In the present stu

• We conducted a retrospective analysis to compare

  2019-05-22

  

  We conducted a retrospective analysis to compare a BMD-alone strategy, versus BMD+FRAX® and BMD+FRAX®+TBS screening strategies. To our knowledge, this constitutes the first study to assess the relative contributions of FRAX® and TBS. In our cohort, FRAX®+BMD identified 9 (9%) additional patients at

• MCs play a key role in the

  2019-05-22

  

  MCs play a key role in the maintaining homeostasis of tissues where they reside by participating in tissue repair, reactions against viral and parasitic infections, and aiding in the regulation of various cell types such as dendritic cells, T cells, and macrophages. In addition, MCs are involved in

• Cyclopamine Supplier We present a case report of a patient w

  2019-05-21

  

  We present a case report of a patient with chronic myeloid leukemia (CML) who developed bilateral renal artery stenosis during tyrosine kinase inhibitor (TKI) therapy. Only a few reports associate TKIs with acute renal failure, and renovascular hypertension has not been previously described. Reports

• But consider the alternative outcomes of so called virtuous

  2019-05-21

  

  But consider the alternative outcomes of so-called virtuous plate-clearing. If the additional portion does not displace other consumption—ie, the amount eaten subsequently is not reduced—then total consumption will have increased. A lack of displacement means no reduction in demand for agricultural

• This trial included patients who

  2019-05-21

  

  This trial included 1500 patients, who met the ICD criteria for primary prevention (non-ischemic, ischemic, dual chamber ICD or CRT-D). The patients were randomized to 3 arms: (1) conventional therapy: Zone 1(VT) 170bpm, 2.5s delay, Zone 2 (VF) 200bpm, 1s delay; (2) high rate therapy: Zone 1(VT) 170

• LQT can have numerous clinical manifestations ranging

  2019-05-21

  

  LQT1 can have numerous clinical manifestations, ranging from no symptoms to sudden cardiac death, which reflects the heterogeneity in channel dysfunction. Mutation type, location, and even a patient׳s ethnic background, age, and gender are critical factors that affect the pathophysiology of the dise

• br En el contexto argentino comprendido entre las d

  2019-05-21

  

  En el contexto argentino comprendido entre las décadas del treinta y del cincuenta, la legitimación del elemento indígena —en su diálogo con los sustratos hispano-colonial e inmigratorio— es emprendida por muy pocos intelectuales provenientes del campo del ensayismo de interpretación nacional. Baj

• Si los sicarios y sus c rteles ejercen un oficio

  2019-05-21

  

  Si los sicarios y sus cárteles ejercen un oficio de tinieblas, donde “madrugar” es uno de los ejes rectores de un México violento, zafio, “kafkiano” y pulsante de impunidad, para Juan Villoro: Circunscrito por el crimen, la miseria y la muerte, el tema de una juventud cercada por la violencia es t

• Ante la necesidad de unas reglas

  2019-05-21

  

  Ante la necesidad de unas reglas o códigos 4-ethylphenyl sulfate partir de los cuales evaluar la producción de los decadentistas, el autor del artículo se lamenta de su inexistencia: “¿Dónde está el código de los decadentistas? No le tienen porque en vez de reglas lo que ellos practican es la violac

• br We sincerely appreciate the

  2019-05-20

  

  We sincerely appreciate the comment by Lombardi et al on our published paper. demonstrates the incidence of dyspnea and the discontinuation of ticagrelor due to dyspnea in patients who reported dyspnea in Phase 3/4 clinical trials of acute coronary syndrome with available relevant data. Our study

• br Initially extrastimulation from the RV at

  2019-05-20

  

  Initially, extrastimulation from the RV at a basic CL of 600ms showed no jump-up phenomenon and VA conduction block at a coupling interval of 480ms (not shown in the figure). The antegrade AVN conduction was evaluated by extrastimulation from the HRA and the ostium of the CS (CSp) at a basic CL of

• br Conflict of interest br Authors contributions br Acknowle

  2019-05-20

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

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