• Unlike our present results in week

  2021-09-11

  

  Unlike our present results in 4–12-week-old (~1–3 months) females, where a high-fat-diet-induced increase in body weight was evident, Schmidt et al. exposed male glut3 mice to a similar high-fat diet (60% kilocalories from fat) and observed no change in body weight, plasma glucose or insulin concent

• With the advent of genome sequencing hexokinase gene sequenc

  2021-09-11

  

  With the advent of genome sequencing, hexokinase gene sequences are now available from a far greater number of vertebrate species, as well as from diverse non-vertebrate animal species. As indicated above, searches of vertebrate genome sequences revealed the existence of a novel fifth member of the

• An advantage of photolabeling with tritiated photoprobes fol

  2021-09-10

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled DL-Menthol and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions with other l

• br Introduction Atrial fibrillation is the most

  2021-09-10

  

  Introduction Atrial fibrillation is the most common cardiac arrhythmia (Benjamin et al., 1998). Pulmonary vein (PV) sleeves contain a mixture of working myocardium and potential arrhythmogenic pacemaker WWL 70 mg behaving as an ectopic trigger of atrial fibrillation (Haissaguerre et al., 1998, C

• Here we showed that microinjection of siRNA at the

  2021-09-10

  

  Here we showed that microinjection of siRNA at the MII stage efficiently reduced endogenous EZH2 mRNA and protein. Although the percentage of cleaving embryos was not affected, Domiphen Bromide formation and blastocyst cell number were both reduced in EZH2 knockdown groups (Table 1). Similar result

• br Conclusions H K demethylases perform an important

  2021-09-10

  

  Conclusions H3K27 demethylases perform an important catalytic function in mediating change in gene expression, whether it is during cell differentiation or activation, because they remove repressive marks from histones which opens the chromatin and facilitates transcription. The number of publica

• The mast cell has long been recognized as central

  2021-09-10

  

  The mast cell has long been recognized as central to the mediation of allergic responses not least because it is the principal repository of histamine in the body. Following activation by allergens, the mast cell can release histamine as well as generate a host of additional mediators such as cystei

• br Retrieval requires histamine H receptors in dorsal hippoc

  2021-09-10

  

  Retrieval requires histamine H1 receptors in dorsal hippocampus Retrieval is a dynamic process that requires neurotransmitter regulation (Barros et al., 2000, Barros et al., 2001). Recently, histamine, and histaminergic transmission has entered the list of putative neurotransmitter modulators of

• The occurrence of naturally HCV NS

  2021-09-10

  

  The occurrence of naturally HCV NS3 resistance-associated substitutions (RAS) affects virological outcome of DAA-based combination therapies [14], [15], [16], [17], [18], [19]. For the majority of NS3 protease inhibitors the frequency of natural occurrence of single RASs in HCV genotype 1-infected p

• br Conclusion br Funding br Availability of data and

  2021-09-10

  

  Conclusion Funding Availability of data and materials Authors' contributions Ethics approval and consent to participate Consent for publication Competing interests Introduction Hepatitis C virus (HCV) infection is a global public health problem. An estimated 71.1 million peop

• In contrast to sGC stimulators sGC activators promote enzyma

  2021-09-10

  

  In contrast to sGC stimulators, sGC activators promote enzymatic activity of sGC containing oxidized heme iron (Fe3+) or missing the heme group. A-350619 is one of the oldest activators of sGC to be discovered. A-350619 increased sGC activation in a non-additive manner with respect to YC-1, leading

• Alzheimer s disease AD is a neurodegenerative disorder

  2021-09-10

  

  Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for

• A similar symbiotic relationship has been reported in

  2021-09-10

  

  A similar symbiotic relationship has been reported in the brain, where increased gradients of lactate secreted by astrocytes enables neurons to import and use this nutrient, a process referred to the ‘neuron–astrocyte lactate shuttle’ [16]. Similarly, lactate-based metabolic coupling established by

• The mD gene obtained from Dr Dimiter

  2021-09-10

  

  The mD1.2 gene obtained from Dr. Dimiter S. Dimitrov was inserted into a pComb3X vector. The transcription and translation of pComb3X plasmid in cells is inhibited by rifampicin, which binds to bacterial DNA-dependent RNA polymerase. However, in the strain BL21 (DE3) expression system, there is over

• Cinobufagin Introduction CD T cell recovery after initiation

  2021-09-10

  

  Introduction CD4+ T cell recovery after initiation of combination antiretroviral therapy (cART) is essential for restoring immune function in HIV-positive individuals [1]. However, CD4 recovery is variable and is affected by factors such as biological sex [2], [3], race [4], BMI [5], geographic reg

15873 records 578/1059 page Previous Next First page 上5页 576577578579580 下5页 Last page