• In a previous study M ykkynen et al

  2022-01-20

  

  In a previous study (Möykkynen et al., 2003), we reported that ethanol lengthens the time needed for the AMPA receptors to recovery from desensitization in isolated hippocampal neurons. Here, we did not observe any effect of ethanol on recovery from desensitization in recombinant homomeric GluR-D re

• In the present study compared to

  2022-01-20

  

  In the present study, compared to diabetic control rats, hepatic glucose-6-phosphatase activity was significantly decreased in both SE and METF treated diabetic animals, with the latter producing greater reduction in glucose-6-phosphatase activity. This observation is consistent with the claim of Ta

• Congenital Gcgr mice exhibit increased hepatic Fgf expressio

  2022-01-20

  

  Congenital Gcgr mice exhibit increased hepatic Fgf21 expression and circulating FGF21 levels. Previous studies by other investigators demonstrated that neutralization of circulating FGF21 with specific APETx2 impairs glucose control in these mice [6]. In addition, the FGF21 analog LY2405319 lowers

• DLS only provides a Z average size based on

  2022-01-20

  

  DLS only provides a Z-average size based on spherical model, hence the size of nanorods was determined as 300 nm by DLS measurement. However, the size of length is nearly 400 nm while width is about 100 nm, which was clearly observed by transmission electron microscopy (TEM) (D). Meanwhile, the TEM

• The only approved H R antagonist inverse agonist is BF

  2022-01-20

  

  The only approved H3R antagonist/inverse agonist is BF2.649 (1- 3-[3-(4-chlorophenyl)propoxy]propyl piperidine), developed by Bioprojet and known as pitolisant (Wakix®). It was approved by the European Medicines Agency in March 2016 and marketed in the European Union to be used in narcolepsy with or

• br Materials and methods br Results br Discussion

  2022-01-20

  

  Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line

• Concerning GST we could appreciate that when snails

  2022-01-19

  

  Concerning GST, we could appreciate that when snails were exposed to the chosen concentrations of chlorpyrifos, the activity was not modified. According to this result, Kristoff et al. (2008) and Domingues et al. (2007) showed no effects on GST in B. glabrata and L. variegatus exposed to azinphos-me

• As well as the above studies

  2022-01-19

  

  As well as the above studies, Meier and coworkers used TUG-891, alongside omega-3 fatty acids, to show a potential role for FFA4 in inhibiting proliferation of DU145 prostate cancer cells [68]. Given that these cells express both FFA4 and FFA1 and the current view that TUG-891 may not be sufficientl

• To evaluate SLC A abundance after

  2022-01-19

  

  To evaluate SLC45A1 abundance after transfection, we performed western blots. Transfected COS-7 Gramine were lysed and separated for membrane fraction. Equal amounts of proteins from membrane fractions were resolved by SDS-PAGE, transferred to a nitrocellulose filter, and immunoblotted with an anti-

• br Materials and methods br Results br Discussion Our data

  2022-01-19

  

  Materials and methods Results Discussion Our data show that the ghrelin receptor, Ghsr, links energy homeostasis with a form of adult hippocampal plasticity. The presence of Ghsr on mature DG neurons suggest that acyl-ghrelin may modulate NSPCs indirectly, possibly via soluble factors such

• This study compared PMS ascorbate and t BHP in

  2022-01-19

  

  This study compared PMS+ascorbate and t-BHP in terms of their effects on the volume-dependent parameters of normal human RBCs. Incubation with both oxidative systems resulted in the RBC density and osmotic resistance distribution shifts. Clotrimazole or Са2+ added into the medium, as well as high ex

• Gap junction channels exhibit different types of gating prop

  2022-01-19

  

  Gap junction channels exhibit different types of gating properties. One alternative mechanism that should be mentioned is loop gating in which the extracellular loop of connexin assumes a configuration to form a narrow pathway for closure of unopposed hemichannels [53] and docked junction channels [

• The structural similarity software vROCS OpenEye has been ut

  2022-01-19

  

  The structural similarity software vROCS (OpenEye) [45] has been utilized by Musumeci et al. [46] to screen the Maybridge [47] HitFinder database (∼14,400 compounds) using Distamycin A (Fig. 3B) as a query. Using the Tanimoto coefficient (Section 6.4) and vROCS's colour scoring (atom/feature similar

• The current gold standard for diagnosing BAM or

  2022-01-19

  

  The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) Tetraethylammonium chloride (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated tau

• br Molecular aberrations in the FGFR signaling

  2022-01-19

  

  Molecular aberrations in the FGFR signaling pathway Non–small cell lung cancer Small cell lung cancer Integrated Toremifene analysis revealed focal amplification of FGFR1 in 6% of SCLC cases. In another study with PD173074, Pardo et al. used two human SCLC xenograft models, H-510 and H-69,

15955 records 506/1064 page Previous Next First page 上5页 506507508509510 下5页 Last page