br Funding This work was supported

2018-10-20

Funding This work was supported by Department of Neurosurgery, the University of Texas Health Science Center at Houston, Memorial Hermann Foundation-Staman Ogilvie Fund, the Bentsen Stroke Center, the TIRR Foundation through Mission Connect (No. 014-115), Craig H. Neilsen Foundation (No. 338617),

Our studies show that only a subpopulation of hESCs

2018-10-20

Our studies show that only a subpopulation of hESCs at the top of the hierarchy possesses an extensive capacity for self-renewal. Polanco et al. recently showed that potassium channel in this compartment could reestablish the continuum of cell states seen in unfractionated cultures (Polanco et al.,

We exploited the fact that the eHBs

2018-10-20

We exploited the fact that the eHBs were trapped as progenitors to analyze the effect of specific growth factors upon them and uncovered a central role for FGF (Figure 6). These data are consistent with studies in which FGF promoted the expansion of BL-CFCs derived from human or murine ESCs (Faloon

br Experimental Procedures br Acknowledgments We

2018-10-20

Experimental Procedures Acknowledgments We thank Ms. Y. Ogata for technical assistance. Financial support for this research was provided by The Uehara Memorial Foundation, and The Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Japan Science and Technology Agen

In this study we found that

2018-10-20

In this study, we found that while zebrafish med14 mutant embryos were largely arrested in development, there was a surprisingly limited effect on overall transcription. Transplantation experiments demonstrated that Med14 function is largely dispensable for cell survival into adulthood. Loss of med1

br Future perspectives Human fetal tissue research and non h

2018-10-20

Future perspectives Human fetal tissue research and non human primate macaque models have been essential to the establishment of human PGCLC differentiation models to study mechanisms that contribute to early PGC allocation in the embryo. Together, these approaches have revealed that humans have

RNA splicing occurs in spliceosomes

2018-10-20

RNA splicing occurs in spliceosomes, which is a complex consisting of RNA and proteins, including five small nuclear RNAs (snRNAs) (U1, U2, U4, U5, and U6 snRNA), hundreds of auxiliary protein factors, and small nuclear ribonucleoproteins (snRNPs) (Reed et al., 1988). The RNA splicing process is cat

br Results br Discussion We examined

2018-10-20

Results Discussion We examined gene expression in human intestinal tissue across the developmental continuum in order to determine maturity of in-vitro-derived HIOs. Using global RNA expression data obtained by RNA-seq, several different analyses demonstrated that the HIO transcriptome closely

Interestingly KLF and TFCP L are

2018-10-20

Interestingly, KLF2 and TFCP2L1 are also involved in LIF/STAT3-mediated ESC self-renewal. KLF2, which is functionally redundant with KLF4, a known target of LIF/STAT3 signaling, can maintain mESCs in an undifferentiated state in the presence of serum (Hall et al., 2009). TFCP2L1, a key target of LIF

br Experimental Procedures br Author Contributions br Acknow

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction The onset of puberty is regulated by a small population of hypothalamic gonadotropin-releasing hormone (GnRH) neurons, which secrete GnRH decapeptide to the hypophyseal portal system. Unlike other neuroendocrine ce

Hello world!

2018-07-29