• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

• cftr channel Active cell proliferation is key for transcript

  2018-10-24

  

  Active cell proliferation is key for transcription factor-induced cell-fate change during cellular reprogramming. Because acute leukemias barely or do not proliferate in vitro, we endeavored to reprogram leukemic B cell lines as well as MLL-rearranged primary blasts induced to proliferate through xe

• br Results Disease modeling using iPSCs can be

  2018-10-24

  

  Results Disease modeling using iPSCs can be confounded by phenotypic variation resulting from genetic differences between individual iPSC lines (Merkle and Eggan, 2013). To overcome this obstacle, we sought to generate isogenic cell lines by targeted correction of the point mutation in the SOD1 i

• To further explore the value of feline liver

  2018-10-24

  

  To further explore the value of feline liver organoids as a research model for steatosis, we tested the effect of small molecules on lipid metabolism. Lipid accumulation was enhanced in the presence of etomoxir, indicating that β-oxidation is an important metabolic pathway handling excess fatty acid

• An approximate solution is sought in the form

  2018-10-24

  

  An approximate solution is sought in the form of an output of an artificial neural network of the given architecture: whose weights are determined when minimizing the error functional and for our case, F(x, y, α) = –α(y – cosx). Test points () are chosen to be random and distributed uniformly

• The results we obtained are also

  2018-10-24

  

  The results we obtained are also in a good agreement with the photoconductivity spectra under excitation by p- or s-polarized light in a structure similar to the one we examined, also containing wide doped QWs [10], where a broad ask1 inhibitor line associated with the 1→e1 and 1→2 transitions was

• Specificity is also valuable in terms of operationalization

  2018-10-24

  

  Specificity is also valuable in terms of operationalization of variables and the conceputalisation of salient environmental correlates in different contexts and population groups. In a sample of 190 older adults in the USA, univariate analyses demonstrated a significant association between physical

• The second implication of our analyses

  2018-10-24

  

  The second implication of our analyses suggests the importance of sociodemographic and structural characteristics, in shaping “behavioral niches” that individuals inhabit and that may shape the organization of health lifestyles. Individual dispositions appear to be grounded in a collective framework

• br Conclusions A premise of

  2018-10-24

  

  Conclusions A premise of evolutionary thought is that each challenge a person faces can be of a different nature and therefore the motivations it mmae stimulates and the actions taken to meet that challenge are also different. For example, the motivations a man feels when he sees the pictures of

• The mayor can also emphasize in the

  2018-10-23

  

  The mayor can also emphasize in the improvement of teaching in the first years of the basic education cycle, to gain quota in the “2nd grade literacy” indicator. However, since 2004 the state government runs (alongside the federal government) a program called PAIC, Program for Literacy at the Approp

• We did not observe that epitope conservation was a

  2018-10-23

  

  We did not observe that epitope conservation was a parameter uniquely shared between LTNP/EC with and without protective alleles. An association between lower HIV RNA levels and preferential recognition of conserved epitopes has been suggested in some acute and chronic infection cohorts regardless o

• Interestingly in their simulation model Lodding and colleagu

  2018-10-23

  

  Interestingly, in their simulation model, Lodding and colleagues were able to predict their real rate of recipients with a high CMV viral load (1.4%, arbitrarily set at >18,200IU/mL) with the assumption of their lower doubling time of 4.3days. Using a shorter doubling time of 1.3days, the proportion

• This study has highlighted the complexity of operationally d

  2018-10-23

  

  This study has highlighted the complexity of operationally defining compensation in neurodegenerative diseases such as HD. The previous literature in HD has thus far failed to address this issue, instead making assumptions of putative compensation based solely on increased activation or connectivity

• Our second objective was to analyze whether certain physicia

  2018-10-23

  

  Our second objective was to analyze whether certain physician characteristics may play a role in these diagnostic and therapeutic decisions. In contrast to what might have been expected, younger cardiologists were not more aggressive than older ones. In fact, if anything, the reverse trend was obser

• Studies using conformational antibodies are indicating

  2018-10-23

  

  Studies using conformational antibodies are indicating that these strains play important roles in toxicity. Sebollela et al. (2014) have shown that NU4, a conformational monoclonal antibody, protected cultured cells from Aβ induced reactive oxygen species production. The study also found that NU4 re

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